Indigestion

Indigestion is a common term (known medically as dyspepsia) covering a variety of symptoms brought on by eating, including heartburn, abdominal pain, nausea, and flatulence (excessive wind in the stomach or intestine, that causes belching and discomfort).

Discomfort in the upper abdomen is often caused by eating too much, too quickly, or by eating very rich, spicy, or fatty foods. Persistent or recurrent indigestion may be due to a peptic ulcer, gallstones, oesophagitis (inflammation of the oesophagus), or, rarely, stomach cancer.

Antacid drugs help to relieve the symptoms, but they may mask an underlying cause that needs medical attention. They should not be taken for longer than two weeks without medical advice.

Definition

Indigestion, which is sometimes called dyspepsia or an upset stomach, is a general term covering a group of nonspecific symptoms in the digestive tract. It is not considered a disease but, rather, several symptoms that are experienced due to impaired digestion of consumed foods. Indigestion is often described as an uncomfortable feeling of fullness, bloating, nausea, heartburn, or gassy discomfort in the chest or upper abdomen. The symptoms develop during meals or shortly afterward. In most cases, indigestion is a minor problem that often clears up without professional treatment.

Demographics

Indigestion is a widespread condition that can occur at any age, for both men and women. It is estimated to occur at some time in 25% of the adult population of the United States.

Description

Most people with indigestion do not feel sick enough to see a doctor; nonetheless, it is a common reason for office visits. About 3% of visits to primary care doctors are for indigestion. Indigestion may only occur occasionally in some people, while others may have it daily.

Causes and symptoms

Physical causes

The symptoms associated with indigestion have a variety of possible physical and lifestyle causes, ranging from commonplace food items to serious systemic disorders:

Diet

Milk, milk products, alcoholic beverages, tea, and coffee cause indigestion in some people because they stimulate the stomach’s production of acid. Chocolate, carbonated beverages, and spicy foods can also cause indigestion.

Medications

Certain prescription drugs as well as over-the-counter medications can irritate the stomach lining. These medications include aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), some antibiotics, digoxin, theophylline, corticosteroids, iron (ferrous sulfate), oral contraceptives, and tricyclic antidepressants.

Disorder of the stomach

Inflammation of the stomach (gastritis)

Disorders of the pancreas and gallbladder

These include inflammation of the gallbladder or pancreas, cancer of the pancreas, and gallstones.

Intestinal parasites

Parasitic infections that cause indigestion include amebiasis, fluke and tapeworm infections, giardiasis, and strongyloidiasis.

Systemic disorders

Including diabetes, thyroid disease, collagen vascular disease.

Cancers of the digestive tract

Such as stomach cancer.

Conditions associated with women’s reproductive organs

These conditions include menstrual cramps, pregnancy, and pelvic inflammatory disease.

Psychological and emotional causes

Indigestion often accompanies an emotional upset, because the part of the nervous system involved in the so-called ‘‘fight-or-flight’’ response also affects the digestive tract. People diagnosed with anxiety, nervousness, or somatoform disorders frequently have problems with indigestion. Many people in the general population, however, will also experience heartburn, ‘‘butterflies in the stomach,’’ or stomach cramps when they are in upsetting situations—such as school examinations, arguments with family members, crises in their workplace, and other such emotional traumas. Some people’s digestive systems appear to react more intensely to emotional stress due to hypersensitive nerve endings in their intestinal tract.

Symptoms

The most common symptoms include:

  • Uncomfortable fullness in the stomach during and/ or after meals, which lasts longer then normal, especially when not eating much food
  • Awareness, mild discomfort, or even more severe pain, in the upper abdominal area, what is called the epigastric area
  • Burning sensation in the upper abdomen (epigastric area)

Less common symptoms are:

  • Bloating, with an uncomfortable feeling of tightness in the stomach
  • Nausea, with a feeling that vomiting may occur
  • Belching or burping

Specific gastrointestinal disorders

In some cases, the patient’s description of the symptoms suggests a specific digestive disorder as the cause of the indigestion. Some doctors classify these cases into three groups.

Esophagitis type 

Esophagitis is an inflammation of the tube that carries food from the throat to the stomach (the esophagus). The tissues of the esophagus can become irritated by the flow (reflux) of stomach acid backward into the lower part of the esophagus. If the patient describes the indigestion in terms of frequent or intense heartburn, the doctor will consider gastroesophageal reflux disease (GERD) as a possible cause. GERD is a common disorder in the general population, affecting about 30% of adults.

Peptic ulcer type

Patients who smoke and are over 45 years of age are more likely to have indigestion of the peptic ulcer type. This group also includes people who find that their indigestion is relieved by taking antacids or eating a small amount of food at each meal. Patients in this category are often found to have Helicobacter pylori infections. H. pylori is a rodshaped bacterium that lives in the tissues of the stomach and causes irritation of the mucous lining of the stomach walls. Most people with H. pylori infections do not develop chronic indigestion, but the organism appears to cause peptic ulcer disease (PUD) in a vulnerable segment of the population.

Non-ulcer type

Most cases of chronic indigestion— as many as 65%—fall into this third category. Non-ulcer dyspepsia is sometimes called functional dyspepsia because it appears to be related to abnormalities in the way that the stomach empties its contents into the intestine. In some people, the stomach empties either too slowly or too rapidly. In others, the stomach’s muscular contractions are irregular and uncoordinated as it receives, digests, and moves foods into the small intestine. These disorders of stomach movement (motility) may be caused by hypersensitive nerve endings in the stomach tissues. Patients in this group are likely to be younger than 45 years and have a history of taking medications for anxiety or depression.

Non-ulcer dyspepsia in more detail

Diagnosis

Patient history

Because indigestion is a nonspecific set of symptoms, patients who feel sick enough to seek medical attention are likely to go to their primary care doctor. The history does not always point to an obvious diagnosis. The doctor can, however, use the process of history-taking to evaluate the patient’s mood or emotional state in order to assess the possibility of a psychiatric disturbance. In addition, asking about the location, intensity, timing, and recurrence of the indigestion can help the doctor weigh the different diagnostic possibilities.

An important part of the history-taking is asking about symptoms that may indicate a serious illness. These warning symptoms include:

  • Weight loss
  • Persistent vomiting
  • Difficulty or pain in swallowing
  • Vomiting blood or passing blood in the stools
  • Anemia

Imaging studies

If the doctor thinks that the indigestion should be investigated further, he or she will order an endoscopic examination of the stomach. An endoscope is a slender tube-shaped instrument that allows the doctor to look at the lining of the patient’s stomach. If the patient has indigestion of the esophagitis type or nonulcer type, the stomach lining will appear normal. If the patient has PUD (peptic ulcer disease) the doctor will be able to see abnormal breaks or ulcerated areas in the tissue. He or she may also order ultrasound imaging of the abdomen, or a radionuclide scan to evaluate the motility of the stomach. Blood, breath, or stool tests may also be ordered to show if a bacterium is causing the problem. In addition, a biopsy may be required to analyze pieces of the affected tissue for damage.

Laboratory tests

Blood tests

If the patient is over 45 years of age, the doctor will have the patient’s blood analyzed for a complete blood cell count, measurements of liver enzyme levels, electrolyte and serum calcium levels, and thyroid function.

Tests for helicobacter pylori

Doctors can now test patients for the presence of Helicobacter pylori without having to take a tissue sample from the stomach. One of these non-invasive tests is a blood test and the other is a breath test.

Treatment

Since most cases of indigestion are not caused by serious disorders, many doctors prefer to try medications and other treatment measures before ordering an endoscopy.

Diet and stress management

Many patients benefit from the doctor’s reassurance that they do not have a serious or fatal disorder. Cutting out alcoholic beverages, drinks containing caffeine, and carbonated beverages often helps. Eliminating tobacco products is also helpful. The patient may also be asked to keep a record of food intake, daily schedule, and symptom severity. Food diaries sometimes reveal psychological or dietary factors that influence indigestion. Eating smaller but more frequent meals can also be beneficial, especially when eaten slowly.

Medications

Patients with the esophagitis type of indigestion are often treated with H2 antagonists. H2 antagonists are drugs that block the secretion of stomach acid. They include ranitidine (Zantac), cimetidine (Tagamet), nizatidine (Axid), and famotidine (Pepcid).

Antacid-type medicines, some found over-thecounter and others with a prescription, are commonly taken to reduce acid production in the stomach. Most of these include different combinations of magnesium, aluminum, and calcium. These medicines are usually found over-the-counter, and include Maalox, Rolaids, Tums, and Mylanta.

Some patients take proton pump inhibitors (PPIs). They are usually given to people who have both indigestion and GERD. PPIs, which also reduce stomach acid, include omeprazole (Prilosec), lansoprazole (Prevacid), and exomeprazole (Nexium).

Patients with motility disorders may be given prokinetic drugs. Prokinetic medications speed up the emptying of the stomach and increase intestinal motility. They include metoclopramide (Reglan) and cisapride (Propulsid). These drugs relieve symptoms in about 75% of patients

Removal of H. pylori

It is not clear that patients with H. pylori infections who have not developed gastric ulcers need to have the bacterium removed. Some studies indicate, however, that these patients may benefit from antibiotic therapy. Some medical authorities advise eradication of helicobacter pylori because it is a carcinogen and increases the risk of stomach cancer. Read more about helicobacter pylori

Alternative treatment

Herbal medicines 

Practitioners of Chinese traditional herbal medicine might recommend medicines derived from peony (Paeonia lactiflora), hibiscus (Hibiscus sabdariffa), or hare’s ear (Bupleurum chinense) to treat indigestion. Western herbalists are likely to prescribe fennel (Foeniculum vulgare), lemon balm (Melissa officinalis), or peppermint (Mentha piperita) to relieve stomach cramps and heartburn.

Homeopathy 

Homeopaths tailor their remedies to the patient’s overall personality profile as well as the specific symptoms. Depending on the patient’s reaction to the indigestion and some of its likely causes, the homeopath might choose Gelsemium (Gelsemium sempervirens), Carbo vegetalis, Nux vomica, or Pulsatilla (Pulsatilla nigricans).

Other treatments

Some alternative treatments are aimed at lowering the patient’s stress level or changing attitudes and beliefs that contribute to indigestion. These therapies and practices include Reiki, reflexology, hydrotherapy, therapeutic massage, yoga, and meditation.

Prognosis

Most cases of mild indigestion do not need medical treatment. For patients who consult a doctor and are given an endoscopic examination, 5 to 15% are diagnosed with GERD and 15 to 25% with PUD. About 1% of patients who are endoscoped have stomach cancer. Most patients with functional dyspepsia do well on either H2 antagonists or prokinetic drugs, depending on the cause of their indigestion.

Prevention

Indigestion can often be prevented by attention to one’s diet, general stress level, and ways of managing stress. Specific preventive measures include:

  • Stop smoking.
  • Cutting down on or eliminating alcohol, tea, or coffee.
  • Avoiding foods that are highly spiced or loaded with fat.
  • Eating slowly and keeping mealtimes relaxed.
  • Practicing yoga or meditation.
  • Not taking aspirin or other medications on an empty stomach.
  • Keeping one’s weight within normal limits.

Read more about diets for indigestion related conditions: