Antimicrobial agents in pregnancy

Antimicrobial agents in pregnancy - technical

A guide to the safety of antimicrobial agents in pregnancy is given in Table 1.

Table 1 A guide to the safety of antimicrobial agents in pregnancy
Drugs Probably safe but limited human studies Potential or proven risk in pregnancy, but benefits may outweigh risk Fetal abnormalities, risk greater than benefit
β-Lactams +    
Aminoglycosides   +  
Macrolides +    
Sulfonamides   +  
Tetracycline     +
Antiparasitic agents, except quinine   +  
Quinine     +
Antimycobacterial agents: INH, pyrazinamide, rifampicin, dapsone, ethambutol   +  
Antimycobacterial agents: ethionamide, thalidomide, clofazimine/cycloserine     +
Aciclovir, valaciclovir, famciclovir +    
Ribavirin     +

Adapted from: Gilbert DN, Moellering RC, Sande MA (2000). The Sandford guide to antimicrobial therapy, 13th edirionn. Antimicrobial Therapy, Inc, Sandford, USA.

 

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